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Akemi Matsuno-Yagi Selected Research

NADH Dehydrogenase

3/2013Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression.
12/2009Parkinson's disease and mitochondrial complex I: a perspective on the Ndi1 therapy.
3/2007Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson's disease.
11/2006The single subunit NADH dehydrogenase reduces generation of reactive oxygen species from complex I.
5/2006Possibility of transkingdom gene therapy for complex I diseases.
1/2006Can a single subunit yeast NADH dehydrogenase (Ndi1) remedy diseases caused by respiratory complex I defects?

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Akemi Matsuno-Yagi Research Topics

Disease

10Parkinson Disease (Parkinson's Disease)
07/2013 - 09/2002
6Mitochondrial Diseases (Mitochondrial Disease)
09/2008 - 03/2005
5Neurodegenerative Diseases (Neurodegenerative Disease)
08/2014 - 09/2002
3Neuroblastoma
03/2007 - 11/2003
2Leber Hereditary Optic Atrophy (Leber's Hereditary Optic Neuropathy)
01/2015 - 07/2010
1Neuroinflammatory Diseases
07/2013
1Weight Gain
07/2013
1Hypokinesia (Bradykinesia)
07/2013
1Breast Neoplasms (Breast Cancer)
03/2013
1Disease Progression
03/2013
1Neoplasm Metastasis (Metastasis)
03/2013
1Neoplasms (Cancer)
03/2013
1Inborn Genetic Diseases (Disease, Hereditary)
12/2010
1Parkinsonian Disorders (Parkinsonism)
01/2007
1Huntington Disease (Huntington's Disease)
09/2002

Drug/Important Bio-Agent (IBA)

7NADH dehydrogenase (quinone)IBA
08/2014 - 09/2004
6RotenoneIBA
01/2015 - 11/2003
6NADH DehydrogenaseIBA
03/2013 - 01/2006
2EnzymesIBA
08/2014 - 10/2013
2NAD (NADH)IBA
03/2013 - 01/2007
2Mitochondrial DNA (mtDNA)IBA
03/2013 - 07/2010
2PesticidesIBA
03/2007 - 11/2003
18-Hydroxy-2'-DeoxyguanosineIBA
07/2013
1DNA (Deoxyribonucleic Acid)IBA
07/2013
1IronIBA
07/2013
1Biomarkers (Surrogate Marker)IBA
07/2013
1Mechanistic Target of Rapamycin Complex 1IBA
03/2013
1Nicotinamide PhosphoribosyltransferaseIBA
03/2013
1Proteins (Proteins, Gene)FDA Link
12/2009
1fenpyroximateIBA
03/2007
1pyridabenIBA
03/2007
1fenazaquinIBA
03/2007
1Oxidoreductases (Dehydrogenase)IBA
01/2007
11- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
01/2007
1Reactive Oxygen Species (Oxygen Radicals)IBA
11/2006
1Amino AcidsFDA Link
03/2005
1Adenosine Triphosphate (ATP)IBA
11/2003
1alpha-SynucleinIBA
11/2003
1AntioxidantsIBA
11/2003
1Electron Transport Complex I (NADH-CoQ Reductase)IBA
09/2002
1Protons (Proton)IBA
09/2002

Therapy/Procedure

3Therapeutics
03/2013 - 11/2003
1Microspheres (Microsphere)
07/2013